Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | PNMT | P11086 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | NOS1 | P29475 | 2/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221816 | 1.00 | TSHR (0.55) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL14033316 | 0.85 | TSHR (0.57) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL18039209 | 0.84 | TSHR (0.55) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL3751585 | 0.83 | PNMT (0.56) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL28739467 | 0.83 | TSHR (0.54) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL3750165 | 0.83 | PNMT (0.56) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL3750842 | 0.83 | PNMT (0.56) | TSHRPNMTSMN1; SMN2TACR1NOS2 | |
| SCHEMBL27588960 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2MEN1MAPK1KMT2ALMNA | |
| SCHEMBL5130053 | 0.81 | PNMT (0.58) | TSHRPNMTSMN1; SMN2TACR1SIGMAR1 | |
| SCHEMBL6003855 | 0.81 | PNMT (0.58) | TSHRPNMTSMN1; SMN2TACR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397358-A1 | TROPANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002102801-A1 | TROPANE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2002-12-27 | — | — | WO | disclosed |