SCHEMBL6573918

SCHEMBL6573918

O=C(CBr)NC(=O)C1CNCCO1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 19/20 0.47
CTSC P53634 1/20 0.39
SSTR1 P30872 1/20 0.39
SSTR2 P30874 1/20 0.39
SSTR3 P32745 1/20 0.39
SSTR5 P35346 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3364696 0.79 SSTR4 (0.41) SSTR4CTSCSSTR1SSTR2SSTR3
SCHEMBL6653458 0.78 GNAI3 (0.45) SSTR4
SCHEMBL6653972 0.78 GNAI3 (0.45) SSTR4
SCHEMBL6651713 0.78 GNAI3 (0.45) SSTR4
SCHEMBL10908504 0.77 SSTR4 (0.53) SSTR4CTSCSSTR1SSTR2SSTR3
SCHEMBL18664465 0.76 SSTR4 (0.52) SSTR4CTSCSSTR1SSTR2SSTR3
SCHEMBL8860932 0.76 SSTR4 (0.52) SSTR4CTSCSSTR1SSTR2SSTR3
SCHEMBL18664463 0.76 SSTR4 (0.52) SSTR4CTSCSSTR1SSTR2SSTR3
SCHEMBL21902109 0.75 SSTR4 (0.55) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL20715370 0.75 SSTR4 (0.55) SSTR4SSTR1SSTR2SSTR3SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1089963-B1 HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE SMITHKLINE BEECHAM PLC (GB) 2004-06-16 EP disclosed
US-6458779-B1 TREATMENT OF CONDITIONS ASSOCIATED WITH EXCESS PRODUCTION OF SOLUBLE CD23 (S-CD23) SUCH AS AUTOIMMUNE DISEASE AND ALLERGY. THE COMPOUNDS OF THE INVENTION ARE ALSO INHIBITORS OF THE RELEASE OF TUMOUR NECROSIS FACTOR (TNF). SMITHKLINE BEECHAM P.L.C. (GB) 2002-10-01 US disclosed
EP-1089963-A1 HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE SMITHKLINE BEECHAM PLC (GB) 2001-04-11 EP disclosed
WO-1999067201-A1 HYDROXAMIC ACID DERIVATIVES AS INHIBITORS OF THE PRODUCTION OF HUMAN CD23 AND OF THE TNF RELEASE SMITHKLINE BEECHAM PLC (GB) 1999-12-29 WO disclosed