Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 2/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6574708 | 1.00 | KMT2A (0.65) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL1876836 | 1.00 | KMT2A (0.65) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL6576259 | 1.00 | KMT2A (0.65) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| SCHEMBL6574075 | 0.98 | DNM1 (0.64) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL7764453 | 0.95 | KMT2A (0.71) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL7760973 | 0.95 | KMT2A (0.71) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL8720796 | 0.95 | KMT2A (0.71) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL11010357 | 0.92 | MEN1 (0.79) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Sulfuric Acid SCHEMBL7765908 | 0.87 | DNM1 (0.58) | KMT2AMEN1MAPK1SMN1; SMN2TP53 | |
| Acetic Acid SCHEMBL7764531 | 0.87 | DNM1 (0.63) | KMT2AMEN1MAPK1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764676-B1 | Method of preparing polycarbonate-polysiloxane block copolymers | GEN ELECTRIC (US) | 2004-04-28 | — | — | EP | claimed |
| EP-0764676-B1 | Method of preparing polycarbonate-polysiloxane block copolymers | GEN ELECTRIC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5616674-A | USING PHASE TRANSFER CATALYSTS | GENERAL ELECTRIC COMPANY (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0764676-A2 | Method of preparing polycarbonate-polysiloxane block copolymers | GENERAL ELECTRIC COMPANY (US) | 1997-03-26 | — | — | EP | disclosed |
| US-4761507-A | Isomerization of linalyl halides with quaternary salts | UNION CAMP CORPORATION (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0132544-B1 | HYDROHALOGENATION OF CONJUGATED DIENES | Union Camp Corporation (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0132543-B1 | ISOMERIZATION OF ALLYLIC HALIDES WITH QUATERNARY SALTS | Union Camp Corporation (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0132543-A1 | Isomerization of allylic halides with quaternary salts | Union Camp Corporation (US) | 1985-02-13 | — | — | EP | disclosed |
| EP-0132544-A1 | Hydrohalogenation of conjugated dienes | Union Camp Corporation (US) | 1985-02-13 | — | — | EP | disclosed |