SCHEMBL6574396

SCHEMBL6574396

COc1ccc(CSC(C)(C)C(=O)Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.46
HTT P42858 2/20 0.44
LDHA P00338 1/20 0.44
EPHX1 P07099 1/20 0.43
F2RL1 P55085 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ALDH1A1 P00352 1/20 0.42
DPP4 P27487 1/20 0.42
DPP7 Q9UHL4 1/20 0.42
FFAR1 O14842 1/20 0.42
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
EPHX2 P34913 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
NR1H4 Q96RI1 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CMA1 P23946 1/20 0.41
GAA P10253 1/20 0.41
TP53 P04637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5757662 0.85 LDHA (0.49) IDO1HTTLDHAEPHX1F2RL1
Hydrochloric Acid SCHEMBL6574400 0.84 IDO1 (0.49) IDO1HTTLDHAEPHX1F2RL1
SCHEMBL27360388 0.84 HTT (0.47) IDO1HTTLDHAF2RL1SMN1; SMN2
SCHEMBL8746134 0.81 IDO1 (0.44) IDO1HTTLDHAEPHX1F2RL1
SCHEMBL7816915 0.80 ALDH1A1 (0.48) IDO1HTTLDHAEPHX1SMN1; SMN2
SCHEMBL24106651 0.80 DPP4 (0.47) IDO1HTTLDHAEPHX1F2RL1
SCHEMBL9712288 0.80 CYP1A2 (0.50) IDO1EPHX1SMN1; SMN2ALDH1A1NPC1
SCHEMBL7668721 0.77 IDO1 (0.52) IDO1SMN1; SMN2ALDH1A1TP53
SCHEMBL6575981 0.77 MEN1 (0.54) IDO1HTTF2RL1SMN1; SMN2ALDH1A1
SCHEMBL8746111 0.76 LDHA (0.46) IDO1HTTLDHAEPHX1F2RL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0785928-B1 NOVEL N3 S2 CHELATING LIGANDS OPTIONALLY RADIOLABELLED WITH Tc OR Re, USEFUL FOR DIAGNOSTIC OR THERAPEUTIC APPLICATIONS MERCK FROSST CANADA INC (CA) 2004-04-28 EP disclosed
EP-0785951-B1 TC OR RE RADIOLABELLED SOMATOSTATIN ANALOGS MERCK FROSST CANADA INC (CA) 2002-04-24 EP disclosed
US-5690904-A BRAIN IMAGING AGENTS AMERSHAM INTERNATIONAL PLC (GB) 1997-11-25 US disclosed
EP-0785928-A1 NOVEL N3 S2 CHELATING LIGANDS OPTIONALLY RADIOLABELLED WITH Tc OR Re, USEFUL FOR DIAGNOSTIC OR THERAPEUTIC APPLICATIONS MERCK FROSST CANADA INC. (CA) 1997-07-30 EP disclosed
EP-0785951-A1 TC OR RE RADIOLABELLED SOMATOSTATIN ANALOGS MERCK FROSST CANADA INC. (CA) 1997-07-30 EP disclosed
US-5632969-A N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications MERCK & CO., INC. (US) 1997-05-27 US disclosed
US-5556939-A TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications MERCK FROSST CANADA, INC. (CA) 1996-09-17 US disclosed
WO-1996011954-A1 TC OR RE RADIOLABELLED SOMATOSTATIN ANALOGS MERCK FROSST CANADA INC. (CA) 1996-04-25 WO disclosed
WO-1996011918-A1 NOVEL N3S2 CHELATING LIGANDS OPTIONALLY RADIOLABELLED WITH Tc OR Re, USEFUL FOR DIAGNOSTIC OR THERAPEUTIC APPLICATIONS MERCK FROSST CANADA INC. (CA) 1996-04-25 WO disclosed