SCHEMBL6575227

SCHEMBL6575227

CCCCCc1cc(C[C@H](OC)C(=O)OCC)ccc1O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT8 Q9H7Z6 2/20 0.41
PPARA Q07869 1/20 0.41
KDM4E B2RXH2 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP3A4 P08684 2/20 0.39
CYP2C8 P10632 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2B6 P20813 2/20 0.39
CYP2C19 P33261 2/20 0.39
NOD2 Q9HC29 1/20 0.39
TYR P14679 1/20 0.39
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
HSP90AA1 P07900 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6575233 1.00 KAT8 (0.41) KAT8PPARAKDM4ECYP1A2CYP3A4
SCHEMBL5389962 0.81 GABRA1 (0.45) CYP3A4GABRA1GABRB2ALDH1A1MEN1
SCHEMBL5377403 0.80 ESR1 (0.46) KDM4ECYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL5382445 0.78 HSD17B2 (0.57) KDM4ECYP3A4ALDH1A1MEN1LMNA
SCHEMBL5380062 0.78 CA2 (0.46) PPARAALDH1A1MEN1HSP90AA1TSHR
SCHEMBL5383353 0.78 CA2 (0.46) PPARAALDH1A1MEN1HSP90AA1TSHR
SCHEMBL14366435 0.78 FOLH1 (0.43) CYP1A2CYP2C9GABRA1GABRB2ALDH1A1
SCHEMBL14392337 0.75 PPARG (0.47) PPARAALOX15
SCHEMBL3694538 0.74 ESR1 (0.51) PPARA
SCHEMBL5360147 0.74 ESR1 (0.51) PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1392637-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2004-03-03 EP disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 WO disclosed