Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 13/20 | 0.66 |
| ▸ | MMP9 | P14780 | 11/20 | 0.66 |
| ▸ | MMP8 | P22894 | 11/20 | 0.66 |
| ▸ | ECE1 | P42892 | 5/20 | 0.62 |
| ▸ | MMP1 | P03956 | 5/20 | 0.58 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.54 |
| ▸ | ADAM12 | O43184 | 1/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | MMP15 | P51511 | 1/20 | 0.54 |
| ▸ | MMP16 | P51512 | 1/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.54 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.54 |
| ▸ | MMP17 | Q9ULZ9 | 1/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371076 | 0.89 | ECE1 (0.76) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL6577392 | 0.89 | ECE1 (0.76) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL6435290 | 0.89 | ECE1 (0.64) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL8651238 | 0.88 | MMP2 (0.73) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL6578096 | 0.81 | MMP2 (0.82) | MMP2MMP9MMP8MMP1ADAM10 | |
| SCHEMBL851449 | 0.81 | MMP2 (0.82) | MMP2MMP9MMP8MMP1ADAM10 | |
| SCHEMBL6575025 | 0.81 | MMP2 (0.85) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL4795667 | 0.81 | MMP2 (0.85) | MMP2MMP9MMP8ECE1MMP1 | |
| SCHEMBL8527775 | 0.81 | ECE1 (0.65) | ECE1 | |
| SCHEMBL8527781 | 0.81 | ECE1 (0.65) | ECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558648-B1 | IMPROVED MATRIX METALLOPROTEASE INHIBITORS | GALARDY RICHARD E (US) | 2004-04-28 | — | — | EP | disclosed |
| EP-0663823-B1 | INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS | GLYCOMED INC (US) | 2000-11-22 | — | — | EP | disclosed |
| EP-0558681-B1 | TREATMENT FOR TISSUE ULCERATION | UNIV FLORIDA (US) | 1998-04-08 | — | — | EP | disclosed |
| EP-0558635-B1 | IMPROVED MATRIX METALLOPROTEASE INHIBITORS | GLYCOMED INC (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0558635-A4 | IMPROVED MATRIX METALLOPROTEASE INHIBITORS | — | 1993-11-24 | — | — | EP | disclosed |
| EP-0558635-A1 | IMPROVED MATRIX METALLOPROTEASE INHIBITORS. | GLYCOMED INC (US) | 1993-09-08 | — | — | EP | disclosed |
| WO-1992009563-A1 | IMPROVED MATRIX METALLOPROTEASE INHIBITORS | GLYCOMED, INC. (US) | 1992-06-11 | — | — | WO | disclosed |