SCHEMBL6578096

SCHEMBL6578096

CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(CC(=O)OC)CC(C)C

nearest known ligand 0.82

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 14/20 0.82
MMP1 P03956 12/20 0.82
MMP9 P14780 9/20 0.82
MMP8 P22894 7/20 0.82
MMP14 P50281 2/20 0.79
ADAM10 O14672 1/20 0.79
ADAM12 O43184 1/20 0.79
ADAMTS4 O75173 1/20 0.79
MMP3 P08254 1/20 0.79
MMP7 P09237 1/20 0.79
MMP12 P39900 1/20 0.79
MMP13 P45452 1/20 0.79
MMP15 P51511 1/20 0.79
MMP16 P51512 1/20 0.79
ADAM17 P78536 1/20 0.79
ADAM9 Q13443 1/20 0.79
MMP26 Q9NRE1 1/20 0.79
MMP17 Q9ULZ9 1/20 0.79
ADAMTS5 Q9UNA0 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL851449 1.00 MMP2 (0.82) MMP2MMP1MMP9MMP8MMP14
SCHEMBL6577392 0.91 ECE1 (0.76) MMP2MMP1MMP9MMP8MMP14
SCHEMBL7371076 0.91 ECE1 (0.76) MMP2MMP1MMP9MMP8MMP14
SCHEMBL13519538 0.91 MMP2 (0.76) MMP2MMP1MMP9MMP8MMP14
SCHEMBL6577835 0.90 MMP1 (0.68) MMP2MMP1MMP9MMP8MMP14
SCHEMBL6577793 0.90 MMP2 (1.00) MMP2MMP1MMP9MMP8MMP14
Ilomastat SCHEMBL8190117 0.88 MMP2 (1.00) MMP2MMP1MMP9MMP8MMP14
Ilomastat SCHEMBL35303 0.88 MMP2 (1.00) MMP2MMP1MMP9MMP8MMP14
Ilomastat SCHEMBL13575799 0.88 MMP2 (1.00) MMP2MMP1MMP9MMP8MMP14
Ilomastat SCHEMBL4293696 0.88 MMP2 (1.00) MMP2MMP1MMP9MMP8MMP14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5892112-A ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS GLYCOMED INCORPORATED (US) 1999-04-06 US claimed
EP-0690841-A4 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INC (US) 1996-03-13 EP claimed
EP-0690841-A1 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INCORPORATED (US) 1996-01-10 EP claimed
WO-1995019965-A1 SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS AND USES THEREOF GLYCOMED INCORPORATED (US) 1995-07-27 WO claimed
EP-0558648-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 2004-04-28 EP disclosed
EP-0663823-B1 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 2000-11-22 EP disclosed
US-5892112-A ACYLATION OF AMINO ACIDS WITH ANHYDRIDES OR CARBOXY GROUPS, AMIDATION WITH AMINE AND CONVERSION OF ACID OR ESTER TO HYDROXAMIC ACID AND HYDROLYSIS GLYCOMED INCORPORATED (US) 1999-04-06 US disclosed
US-5773438-A SKIN DISORDERS, RESTENOSIS, RHEUMATIC ARTHRITIS, WOUND HEALING AGENTS, ANGIOGENESIS, SHOCK GLYCOMED INCORPORATED (US) 1998-06-30 US disclosed
EP-0558681-B1 TREATMENT FOR TISSUE ULCERATION UNIV FLORIDA (US) 1998-04-08 EP disclosed
US-5696147-A CONTROLLING GROWTH OF TUMORS AND NEOVASCULAR GLAUCOMAS GLYCOMED, INC. (US) 1997-12-09 US disclosed
EP-0558635-B1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED INC (US) 1997-09-10 EP disclosed
EP-0663823-A4 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS. GLYCOMED INC (US) 1997-06-04 EP disclosed
EP-0558648-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY, Richard, E. (US) 1993-09-08 EP disclosed
US-5239078-A Collagenase enzyme inhibitors GLYCOMED INCORPORATED (US) 1993-08-24 US disclosed
WO-1993013741-A2 INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1993-07-22 WO disclosed
US-5189178-A Preventing protein destruction GALARDY RICHARD E (US) 1993-02-23 US disclosed
US-5183900-A Matrix metalloprotease inhibitors GALARDY RICHARD E (US) 1993-02-02 US disclosed
WO-1992009556-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GALARDY RICHARD E (US) 1992-06-11 WO disclosed
WO-1992009563-A1 IMPROVED MATRIX METALLOPROTEASE INHIBITORS GLYCOMED, INC. (US) 1992-06-11 WO disclosed
US-5114953-A Peptides UNIVERSITY OF FLORIDA (US) 1992-05-19 US disclosed