Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.37 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6579447 | 0.99 | HTR6 (0.46) | HTR6GAAHTR2AADRB2HTR1D | |
| SCHEMBL6579474 | 0.82 | ADRB2 (0.53) | HTR6GAAHTR2AADRB2HTR1D | |
| Hydrochloric Acid SCHEMBL6577815 | 0.81 | ADRB2 (0.52) | HTR6GAAHTR2AADRB2HTR1D | |
| SCHEMBL6577839 | 0.72 | HTR2A (0.57) | HTR6HTR2AADRB2HTR1D | |
| Hydrochloric Acid SCHEMBL6580166 | 0.72 | HTR2A (0.56) | HTR6HTR2AADRB2HTR1D | |
| SCHEMBL27873084 | 0.69 | ADRB2 (0.58) | HTR6HTR2AADRB2HTR1DMTNR1A | |
| SCHEMBL18404868 | 0.68 | HTR2A (0.63) | HTR6HTR2AADRB2HTR1DTAAR1 | |
| SCHEMBL6577326 | 0.68 | HTR1D (0.68) | HTR6HTR2AHTR1DTAAR1KMT2A | |
| SCHEMBL7163717 | 0.68 | HTR6 (0.43) | HTR6GAAMTNR1AMTNR1BKMT2A | |
| SCHEMBL27867012 | 0.68 | ADRB2 (0.57) | HTR6HTR2AADRB2HTR1DMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411925-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2003011284-A1 | 5-ARYLSULFONYL INDOLES HAVING 5-HT6 RECEPTOR AFFINITY | PHARMACIA & UPJOHN COMPANY (US) | 2003-02-13 | — | — | WO | claimed |