SCHEMBL6575650

SCHEMBL6575650

CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 15/20 0.59
MAPT P10636 3/20 0.57
KMT2A Q03164 3/20 0.57
KDM4E B2RXH2 2/20 0.57
MEN1 O00255 2/20 0.57
CYP1A2 P05177 2/20 0.57
CYP3A4 P08684 2/20 0.57
TSHR P16473 2/20 0.57
PTGS1 P23219 2/20 0.57
PTGS2 P35354 2/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
MLNR O43193 1/20 0.57
LMNA P02545 1/20 0.57
MMP1 P03956 1/20 0.57
MPO P05164 1/20 0.57
GLA P06280 1/20 0.57
ADORA3 P0DMS8 1/20 0.57
CYP2C9 P11712 1/20 0.57
HPGD P15428 1/20 0.57
TBXA2R P21731 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methanesulfonamide SCHEMBL4796610 0.97 CYP19A1 (0.57) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL3237240 0.85 CYP19A1 (0.64) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL10658813 0.82 CYP19A1 (0.61) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL11059382 0.81 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL8661575 0.81 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL2122759 0.81 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL6816523 0.81 CRHBP (0.65) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL8980028 0.80 MAPT (0.63) MAPTKMT2AMEN1TSHRSMN1; SMN2
SCHEMBL14428338 0.79 MAPT (0.75) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL5201193 0.79 MCL1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1066264-B1 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS OREAL (FR) 2004-11-17 EP disclosed
US-6537329-B1 Intense colorations with a wide range of colours, excellent colorfastness L'OREAL S.A. (FR) 2003-03-25 US disclosed
EP-1066264-A2 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS L'OREAL (FR) 2001-01-10 EP disclosed
WO-2000042971-A2 NOVEL CATIONIC 2-SULPHONYLAMINOPHENOLS, THEIR USE AS COUPLERS FOR OXIDATION DYEING, COMPOSITIONS CONTAINING THEM AND DYEING METHODS L'OREAL (FR) 2000-07-27 WO disclosed
US-5776984-A NAPTHYL DERIVATIVES OF BENZENESULFONAMIDES ABBOTT LABORATORIES (US) 1998-07-07 US disclosed
US-5681842-A Prostaglandin synthase-2 inhibitors ABBOTT LABORATORIES (US) 1997-10-28 US disclosed