Methanesulfonamide

Methanesulfonamide

SCHEMBL4796610

CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1O.CS(N)(=O)=O

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 16/20 0.57
MAPT P10636 3/20 0.54
KMT2A Q03164 3/20 0.54
KDM4E B2RXH2 2/20 0.54
MEN1 O00255 2/20 0.54
CYP1A2 P05177 2/20 0.54
CYP3A4 P08684 2/20 0.54
TSHR P16473 2/20 0.54
PTGS1 P23219 2/20 0.54
PTGS2 P35354 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
MLNR O43193 1/20 0.54
LMNA P02545 1/20 0.54
MMP1 P03956 1/20 0.54
MPO P05164 1/20 0.54
GLA P06280 1/20 0.54
ADORA3 P0DMS8 1/20 0.54
CYP2C9 P11712 1/20 0.54
HPGD P15428 1/20 0.54
TBXA2R P21731 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6575650 0.97 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL3237240 0.82 CYP19A1 (0.64) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL11059382 0.81 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL10658813 0.80 CYP19A1 (0.61) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL8661575 0.78 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL6816523 0.78 CRHBP (0.65) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL2122759 0.78 CYP19A1 (0.59) CYP19A1MAPTKMT2AKDM4EMEN1
SCHEMBL9769660 0.77 GPR35 (0.56) MAPTKMT2AKDM4EMEN1TSHR
SCHEMBL6573116 0.77 EP300 (0.50) MAPTKMT2AKDM4EMEN1CYP3A4
SCHEMBL8980028 0.77 MAPT (0.63) MAPTKMT2AMEN1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1984325-A2 SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2008-10-29 EP disclosed
WO-2007120379-A2 SULFONANILIDE ANALOGS AS SELECTIVE AROMATASE MODULATORS THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2007-10-25 WO disclosed