Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 7/20 | 0.50 |
| ▸ | RARG | P13631 | 6/20 | 0.50 |
| ▸ | RARA | P10276 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577982 | 0.87 | RARB (0.66) | RARBRARGRARACYP3A4 | |
| SCHEMBL8634937 | 0.82 | RARB (0.74) | MAPK1RARBRARGRARAKMT2A | |
| SCHEMBL6578640 | 0.82 | RARB (0.49) | MAPK1RARBRARGRARAALDH1A1 | |
| SCHEMBL8616526 | 0.77 | RARB (0.42) | RARBRARGRARACACNA1BAPBA1 | |
| SCHEMBL6576642 | 0.77 | POLB (0.41) | MAPK1RARBRARGRARAALDH1A1 | |
| SCHEMBL8634168 | 0.77 | RARB (0.74) | MAPK1RARBRARGRARAKMT2A | |
| SCHEMBL8605778 | 0.76 | RARB (0.61) | MAPK1RARBRARGRARAKMT2A | |
| SCHEMBL8866305 | 0.74 | RARB (0.71) | MAPK1RARBRARGRARAALDH1A1 | |
| SCHEMBL8614817 | 0.74 | RARB (0.52) | RARBRARGRARAALDH1A1GAA | |
| SCHEMBL8606834 | 0.74 | RARB (0.51) | MAPK1RARBRARGRARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5739338-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS, VISION DEFECTS, VIRICIDES, IMMUNOSUPPRESSANTS | ALLERGAN (US) | 1998-04-14 | — | — | US | disclosed |