Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.49 |
| ▸ | RARA | P10276 | 10/20 | 0.49 |
| ▸ | RARG | P13631 | 9/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614817 | 0.92 | RARB (0.52) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL6578028 | 0.88 | RARB (0.41) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL6578025 | 0.87 | RARB (0.65) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6575692 | 0.82 | MAPK1 (0.53) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9484975 | 0.79 | RARB (0.67) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL6574370 | 0.78 | RARB (0.67) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6576434 | 0.77 | RARB (0.48) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6575696 | 0.76 | RARB (0.46) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL6575676 | 0.76 | RARB (0.39) | RARBRARARARGCYP3A4CYP26A1 | |
| SCHEMBL5737868 | 0.75 | RARB (0.52) | RARBRARARARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937045-B1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN INC (US) | 2004-04-28 | — | — | EP | disclosed |
| US-5739338-A | SKIN DISORDERS, ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENTS, VISION DEFECTS, VIRICIDES, IMMUNOSUPPRESSANTS | ALLERGAN (US) | 1998-04-14 | — | — | US | disclosed |