Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5865252 | 0.83 | SMN1; SMN2 (0.40) | TSHRMAPK1TDP1L3MBTL1KDM4E | |
| SCHEMBL5865511 | 0.82 | L3MBTL1 (0.53) | TSHRMAPK1TDP1CYP3A4ATM | |
| SCHEMBL5865399 | 0.82 | TSHR (0.53) | TSHRMAPK1HIF1ATDP1CYP3A4 | |
| SCHEMBL5865564 | 0.74 | MAPT (0.43) | TSHRMAPK1TDP1CYP3A4ATM | |
| SCHEMBL5865494 | 0.72 | TSHR (0.50) | TSHRMAPK1CYP3A4ATML3MBTL1 | |
| SCHEMBL5865629 | 0.71 | MAPK1 (0.53) | TSHRMAPK1CYP3A4ATML3MBTL1 | |
| SCHEMBL5865539 | 0.69 | MAPK1 (0.50) | TSHRMAPK1CYP3A4ATML3MBTL1 | |
| SCHEMBL5865619 | 0.64 | CCR2 (0.41) | TSHRMAPK1CYP3A4ATML3MBTL1 | |
| SCHEMBL27397701 | 0.64 | SMN1; SMN2 (0.40) | TSHRCYP3A4L3MBTL1KDM4ECA1 | |
| SCHEMBL19157375 | 0.64 | SMN1; SMN2 (0.46) | TSHRTDP1L3MBTL1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412311-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | Brandt, Ingvar (SE) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003002495-A1 | NOVEL TREATMENT OF ADRENOCORTICAL HYPERSECRETION AND TUMOUR GROWTH | BRANDT INGVAR (SE) | 2003-01-09 | — | — | WO | disclosed |