SCHEMBL6575833

SCHEMBL6575833

Cc1cc(N)c(CCO)cc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.38
ALOX15 P16050 4/20 0.38
HSD17B10 Q99714 4/20 0.38
CYP1A2 P05177 2/20 0.38
HIF1A Q16665 2/20 0.38
TSHR P16473 2/20 0.38
CASP7 P55210 1/20 0.38
CASP1 P29466 1/20 0.38
PDE10A Q9Y233 1/20 0.38
MAPK1 P28482 3/20 0.37
KDM4E B2RXH2 3/20 0.37
MAPT P10636 3/20 0.37
CYP3A4 P08684 2/20 0.37
PKM P14618 2/20 0.37
CYP2D6 P10635 1/20 0.37
G6PD P11413 1/20 0.37
CYP2C9 P11712 1/20 0.37
HPGD P15428 1/20 0.37
ALOX12 P18054 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9385877 0.84 ALDH1A1 (0.42) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL29634741 0.83 ALDH1A1 (0.50) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL94261 0.83 ALDH1A1 (0.50) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
Hydrochloric Acid SCHEMBL7861016 0.82 ALDH1A1 (0.48) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
Hydrochloric Acid SCHEMBL7861014 0.82 ALDH1A1 (0.48) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL5694433 0.79 ALDH1A1 (0.61) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL14755445 0.77 ALDH1A1 (0.46) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL16932994 0.75 ALDH1A1 (0.37) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL29265971 0.73 PTK2 (0.42) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A
SCHEMBL3077884 0.73 ALDH1A1 (0.50) ALDH1A1ALOX15HSD17B10CYP1A2HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0920853-B1 Hair dye compositions P & G CLAIROL INC (US) 2004-01-21 EP disclosed
EP-0920853-A1 Hair dye compositions Bristol-Myers Squibb Company (US) 1999-06-09 EP disclosed