Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578278 | 0.93 | MAPT (0.55) | CES2CES1MAPTALDH1A1HTR1A | |
| SCHEMBL6576227 | 0.87 | CES1 (0.53) | CES2CES1MAPTALDH1A1HTR1A | |
| SCHEMBL4477185 | 0.85 | CES1 (0.70) | CES2CES1MAPTALDH1A1HTR1A | |
| SCHEMBL11427588 | 0.79 | MAPK1 (0.47) | CES1MAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL9787226 | 0.78 | MAPT (0.64) | CES2CES1MAPTALDH1A1KDM4E | |
| SCHEMBL240086 | 0.78 | GSK3B (0.71) | CES2CES1ALDH1A1HSD11B1GSK3B | |
| SCHEMBL522192 | 0.76 | ALDH1A1 (0.64) | CES2CES1MAPTALDH1A1HTR1A | |
| SCHEMBL23253123 | 0.75 | HSD11B1 (0.52) | CES2CES1MAPTALDH1A1HSD11B1 | |
| SCHEMBL6650467 | 0.75 | GSK3B (0.62) | CES2CES1MAPTALDH1A1HSD11B1 | |
| SCHEMBL9207986 | 0.75 | CES1 (0.70) | CES2CES1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870762-B1 | NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP | SANTEN PHARMACEUTICAL CO LTD (JP) | 2004-04-28 | — | — | EP | disclosed |
| US-5872281-A | COMPOUNDS FOR TREATMENT OF RHEUMATIC DISEASES, PSORIASIS, INTESTINAL INFLAMATION | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1999-02-16 | — | — | US | disclosed |
| EP-0870762-A1 | NOVEL AMINO ACID DERIVATIVES HAVING N,N-DIALKYLAMINOPHENYL GROUP | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1998-10-14 | — | — | EP | disclosed |