Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | HRAS | P01112 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7116896 | 0.88 | POLB (0.35) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6776323 | 0.86 | TDP1 (0.36) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL6576431 | 0.79 | AR (0.39) | POLBNPC1RAB9AMEN1KMT2A | |
| SCHEMBL7541678 | 0.74 | HRAS (0.53) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL7119707 | 0.73 | HRAS (0.57) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL3459108 | 0.73 | HRAS (0.51) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL7117804 | 0.73 | HRAS (0.48) | POLBTOP1HRASESR1ESR2 | |
| Brostallicin SCHEMBL3678233 | 0.73 | HRAS (0.56) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL7127024 | 0.73 | HRAS (0.56) | POLBTOP1HRASESR1ESR2 | |
| SCHEMBL7118414 | 0.73 | HRAS (0.48) | POLBTOP1HRASESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951951-B2 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2005-10-04 | — | — | US | disclosed |
| US-6753316-B1 | 3-ACRYLAMIDOPYRAZOLE-5-CARBOXAMIDE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-06-22 | — | — | US | disclosed |
| US-20040082759-A1 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2004-04-29 | — | — | US | disclosed |
| US-20040029810-A1 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2004-02-12 | — | — | US | disclosed |
| CN-1116281-C | Acryloyl substituted distamycin derivatives, process for their preparation, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN SPA (IT) | 2003-07-30 | — | — | CN | disclosed |
| EP-1324983-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | Pharmacia Italia S.p.A. (IT) | 2003-07-09 | — | — | EP | disclosed |
| EP-1311481-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | Pharmacia Italia S.p.A. (IT) | 2003-05-21 | — | — | EP | disclosed |
| US-20030023031-A1 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN S.P.A. | 2003-01-30 | — | — | US | disclosed |
| US-6482920-B1 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | PHARMACIA ITALIA, S.P.A. (IT) | 2002-11-19 | — | — | US | disclosed |
| EP-1242374-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-09-25 | — | — | EP | disclosed |
| WO-2002008184-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |
| WO-2002002523-A1 | PROCESS FOR PREPARING DISTAMYCIN DERIVATIVES | PHARMACIA ITALIA S.P.A. (IT) | 2002-01-10 | — | — | WO | disclosed |
| EP-0915845-B1 | ACRYLOYL SUBSTITUTED DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS | PHARMACIA & UPJOHN SPA (IT) | 2001-09-12 | — | — | EP | disclosed |
| WO-2001040181-A1 | ACRYLOYL PEPTIDIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2001-06-07 | — | — | WO | disclosed |
| CN-1226232-A | Acryloyl substituted distamycin derivatives, process for their preparation, and their use as antitumor and antiviral agents | PHARMACIA & UPJOHN SPA (IT) | 1999-08-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029810-A1 | Process for preparing distamycin derivatives | RPN2, DHPS, MYD88 | POLB 1267/4885NPC1 786/4885RAB9A 949/4885 |
| US-20040082759-A1 | Process for preparing distamycin derivatives | GSTP1, GSTA1, GSS | POLB 2044/4885NPC1 1136/4885RAB9A 405/4885 |
| US-20030023031-A1 | Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents | EIF2AK2, ACR, EIF4A1 | POLB 2369/4885NPC1 19/4885RAB9A 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.