Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 9/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6577829 | 1.00 | APEX1 (0.42) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL6339714 | 0.68 | APEX1 (0.44) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL8569858 | 0.68 | APEX1 (0.49) | APEX1MAPTTDP1ALDH1A1THRB | |
| Aurantiogliocladin SCHEMBL487583 | 0.67 | MAPT (0.50) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL7324226 | 0.67 | APEX1 (0.45) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL11168354 | 0.66 | APEX1 (0.47) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL3754346 | 0.63 | APEX1 (0.74) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL2625087 | 0.63 | LMNA (0.68) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL3754350 | 0.63 | APEX1 (0.74) | APEX1MAPTTDP1ALDH1A1THRB | |
| SCHEMBL13033957 | 0.63 | MAPT (0.61) | APEX1MAPTTDP1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0643775-B1 | QUINONE DERIVATIVES FOR ENHANCING CELLULAR BIOENERGY | CT FOR MOLECULAR BIOLOGY AND M (AU) | 2004-07-21 | — | — | EP | disclosed |
| US-5981601-A | Method for enhancing cellular bioenergy | CENTRE FOR MOLECULAR BIOLOGY AND MEDICINE (AU) | 1999-11-09 | — | — | US | disclosed |
| EP-0643775-A4 | THERAPEUTIC COMPOSITIONS. | UNIV MONASH (AU) | 1995-12-27 | — | — | EP | disclosed |
| EP-0643775-A1 | THERAPEUTIC COMPOSITIONS | MONASH UNIVERSITY (AU) | 1995-03-22 | — | — | EP | disclosed |
| WO-1993024650-A1 | THERAPEUTIC COMPOSITIONS | MONASH UNIVERSITY (AU) | 1993-12-09 | — | — | WO | disclosed |