Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.60 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.48 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657823 | 0.93 | PRKCZ (0.53) | PRKCZGRIN1GRIN2BRAB9A | |
| SCHEMBL659146 | 0.91 | PRKCZ (0.73) | PRKCZGRIN1GRIN2BPIN1RAB9A | |
| SCHEMBL659145 | 0.83 | PRKCZ (0.64) | PRKCZRAB9A | |
| SCHEMBL2303038 | 0.82 | PRKCZ (0.72) | PRKCZGRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL658866 | 0.82 | PRKCZ (0.63) | PRKCZRAB9A | |
| SCHEMBL2305627 | 0.77 | PRKCZ (0.70) | PRKCZPIN1 | |
| SCHEMBL659484 | 0.77 | PRKCZ (0.83) | PRKCZPIN1RAB9A | |
| SCHEMBL10252755 | 0.76 | PRKCZ (0.78) | PRKCZPIN1RAB9A | |
| SCHEMBL2304303 | 0.76 | PRKCZ (0.78) | PRKCZPIN1RAB9A | |
| SCHEMBL2301693 | 0.75 | PRKCZ (1.00) | PRKCZPIN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349999-B1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIV SAARLAND (DE) | 2016-01-27 | — | — | EP | disclosed |
| US-8912186-B2 | Allosteric protein kinase modulators | UNIVERSITAET DES SAARLANDES (DE) | 2014-12-16 | — | — | US | disclosed |
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2012-02-23 | — | — | US | disclosed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010043711-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | UNIVERSITAET DES SAARLANDES (DE) | 2010-04-22 | — | — | WO | disclosed |
| EP-2177510-A1 | Allosteric protein kinase modulators | Universität des Saarlandes (DE) | 2010-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046307-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | AURKC, AURKA, AURKB | PRKCZ 26/4885GRIN1 2290/4885GRIN2B 3667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.