SCHEMBL6578267

SCHEMBL6578267

COc1ccc(CSC(C)(C)CN)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.62
CYP1A2 P05177 1/20 0.62
CYP2D6 P10635 1/20 0.62
PRMT1 Q99873 1/20 0.62
IDO1 P14902 5/20 0.50
TAAR1 Q96RJ0 1/20 0.48
APP P05067 1/20 0.47
MAOB P27338 5/20 0.44
TSHR P16473 2/20 0.44
AGXT P21549 2/20 0.44
MAOA P21397 1/20 0.44
ALDH1A1 P00352 1/20 0.43
TP53 P04637 1/20 0.43
ALOX15 P16050 1/20 0.43
ALOX12 P18054 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20435360 0.86 TAAR1 (0.50) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL7798995 0.85 CYP3A4 (0.46) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL11490965 0.84 IDO1 (0.51) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL16589112 0.83 IDO1 (0.47) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL7668721 0.81 IDO1 (0.52) CYP3A4IDO1TAAR1APPMAOB
SCHEMBL8376336 0.81 MEN1 (0.47) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL7798992 0.80 TAAR1 (0.44) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL30657036 0.80 TAAR1 (0.44) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL20425216 0.79 IDO1 (0.47) CYP3A4CYP1A2CYP2D6PRMT1IDO1
SCHEMBL20287965 0.79 ALDH1A1 (0.44) CYP3A4CYP1A2CYP2D6PRMT1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929319-B1 DOPAMINE AND SEROTONIN TRANSPORTER LIGANDS AND IMAGING AGENTS UNIV PENNSYLVANIA (US) 2004-09-22 EP disclosed
US-6241963-B1 COMPRISING DERIVATIVES OF 5-PHENYL-8-AZABICYCLO(3.2.1)OCTANE BEARING TECHNECIUM- OR RHENIUM-CHELATING MOIETIES ON THE NITROGEN; SPECIFIC TO CENTRAL NERVOUS SYSTEM RECEPTOR BINDING THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2001-06-05 US disclosed
US-5980860-A A TROPANE-BASED DERIVATIVE COMPLEXES WITH EITHER TECHNETIUM OR RHENIUM THAT ARE SPECIFIC FOR CENTRAL NERVOUS SYSTEM RECEPTORS THE TRUSTEES OF UNIVERSITY OF PENNSYLVANIA (US) 1999-11-09 US disclosed
EP-0929319-A1 DOPAMINE AND SEROTONIN TRANSPORTER LIGANDS AND IMAGING AGENTS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1999-07-21 EP disclosed
EP-0929319-A4 UNIV PENNSYLVANIA (US) 1999-07-21 EP disclosed
US-5690904-A BRAIN IMAGING AGENTS AMERSHAM INTERNATIONAL PLC (GB) 1997-11-25 US disclosed
WO-1997014445-A1 DOPAMINE AND SEROTONIN TRANSPORTER LIGANDS AND IMAGING AGENTS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1997-04-24 WO disclosed