SCHEMBL6578508

SCHEMBL6578508

COc1ccc(-c2nc(-c3cccc(CN4CCCC4)c3)n(C)n2)cc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.55
ADORA1 P30542 1/20 0.55
DRD2 P14416 2/20 0.52
DRD4 P21917 2/20 0.52
DRD3 P35462 2/20 0.52
ACP1 P24666 4/20 0.50
TMEM97 Q5BJF2 2/20 0.50
HRH3 Q9Y5N1 1/20 0.49
AVPR1B P47901 3/20 0.48
SIGMAR1 Q99720 2/20 0.47
CNR1 P21554 1/20 0.46
CNR2 P34972 1/20 0.46
CHKA P35790 1/20 0.46
MCHR1 Q99705 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6578595 0.99 ADORA2A (0.54) ADORA2AADORA1DRD2DRD4DRD3
Hydrochloric Acid SCHEMBL6578615 0.95 DRD2 (0.51) ADORA2AADORA1DRD2DRD4DRD3
SCHEMBL6578571 0.89 ADORA2A (0.68) ADORA2AADORA1DRD2DRD4DRD3
Hydrochloric Acid SCHEMBL6580643 0.88 ADORA2A (0.67) ADORA2AADORA1DRD2DRD4DRD3
SCHEMBL6578760 0.87 AVPR1B (0.51) DRD2DRD4DRD3ACP1HRH3
Hydrochloric Acid SCHEMBL6581009 0.86 AVPR1B (0.50) DRD2DRD4DRD3ACP1HRH3
Hydrochloric Acid SCHEMBL6578233 0.85 NR1H3 (0.62) DRD2DRD4DRD3ACP1TMEM97
Hydrochloric Acid SCHEMBL6580767 0.85 AVPR1B (0.56) DRD2DRD4DRD3ACP1AVPR1B
Hydrochloric Acid SCHEMBL6581333 0.83 AVPR1B (0.47) DRD2DRD4DRD3ACP1HRH3
Hydrochloric Acid SCHEMBL6580578 0.82 NR1H3 (0.54) DRD2DRD4DRD3ACP1TMEM97

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP claimed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US claimed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP claimed
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP disclosed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US disclosed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP disclosed