Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.59 |
| ▸ | RXRA | P19793 | 1/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584177 | 0.95 | SMPD1 (0.81) | KDM4EALDH1A1MAPTSMPD1HDAC1 | |
| SCHEMBL24077087 | 0.89 | SMPD1 (0.72) | KDM4EALDH1A1MAPTSMPD1HDAC1 | |
| SCHEMBL28325672 | 0.89 | SMPD1 (0.90) | KDM4ESMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL4278415 | 0.86 | NPC1 (0.73) | KDM4EALDH1A1MAPTSMPD1HDAC1 | |
| SCHEMBL2063068 | 0.86 | SMN1; SMN2 (0.73) | KDM4EALDH1A1MAPTSMPD1HDAC1 | |
| SCHEMBL242563 | 0.86 | MRGPRX4 (0.77) | KDM4ESMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL27881765 | 0.86 | NPC1 (0.77) | KDM4EMAPTSMPD1HDAC1HDAC8 | |
| SCHEMBL7237622 | 0.85 | ALDH1A1 (0.63) | KDM4EALDH1A1MAPTSMPD1HDAC1 | |
| SCHEMBL11277266 | 0.85 | MRGPRX4 (0.75) | KDM4ESMPD1HDAC1HDAC8HDAC6 | |
| SCHEMBL31025721 | 0.85 | NPC1 (0.75) | KDM4EMAPTSMPD1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1148357-C | Triazole and imidazole derivative | - | 2004-05-05 | — | — | CN | disclosed |
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| CN-1281852-A | Triazole and imidazole derivative | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |