Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578097 | 0.95 | CA2 (0.35) | DUTCA1CA2 | |
| SCHEMBL6655379 | 0.85 | DUT (0.35) | DUTCA1CA2 | |
| SCHEMBL6577285 | 0.83 | DUT (0.35) | DUTCA1CA2 | |
| SCHEMBL16898660 | 0.81 | DUT (0.40) | DUTCA1CA2 | |
| SCHEMBL31171203 | 0.81 | DUT (0.40) | DUTCA1CA2 | |
| SCHEMBL12013275 | 0.81 | DUT (0.40) | DUTCA1CA2 | |
| SCHEMBL4949086 | 0.80 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL4949681 | 0.80 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL4953881 | 0.80 | CA2 (0.43) | CA1CA2 | |
| SCHEMBL11903406 | 0.79 | CA1 (0.32) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867438-B1 | Rapamycin derivatives and their use, particularly as immunosuppressants | NOVARTIS AG (CH) | 2004-07-28 | — | — | EP | disclosed |
| EP-1413581-A1 | Rapamycin derivatives | Novartis AG (CH) | 2004-04-28 | — | — | EP | disclosed |
| EP-0867438-A1 | Rapamycin derivatives and their use, particularly as immunosuppressants | Novartis AG (CH) | 1998-09-30 | — | — | EP | disclosed |
| US-5665772-A | O-alkylated rapamycin derivatives and their use, particularly as immunosuppressants | SANDOZ LTD. (CH) | 1997-09-09 | — | — | US | disclosed |
| EP-0663916-A1 | O-ALKYLATED RAPAMYCIN DERIVATIVES AND THEIR USE, PARTICULARLY AS IMMUNOSUPPRESSANTS | SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. (AT) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994009010-A1 | O-ALKYLATED RAPAMYCIN DERIVATIVES AND THEIR USE, PARTICULARLY AS IMMUNOSUPPRESSANTS | SANDOZ LTD. (CH) | 1994-04-28 | — | — | WO | disclosed |