Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.79 |
| ▸ | BRD4 | O60885 | 8/20 | 0.79 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.76 |
| ▸ | BRD2 | P25440 | 1/20 | 0.75 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.75 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.70 |
| ▸ | PRKACA | P17612 | 2/20 | 0.70 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.70 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.70 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.70 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.70 |
| ▸ | PRKCB | P05771 | 1/20 | 0.70 |
| ▸ | PRKCA | P17252 | 1/20 | 0.70 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579108 | 0.91 | MAPK14 (0.78) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6581980 | 0.88 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730440 | 0.88 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730369 | 0.87 | MAPK14 (0.85) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730405 | 0.86 | BRD4 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL22730357 | 0.86 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6579262 | 0.85 | MAPK14 (0.75) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL4914492 | 0.85 | MAPK14 (1.00) | MAPK14BRD4BRDTPRKD3MAP4K4 | |
| SCHEMBL1640306 | 0.84 | MAPK14 (1.00) | MAPK14BRD4BRDTBRD2BRD3 | |
| SCHEMBL6578983 | 0.82 | MAPK14 (0.91) | MAPK14BRD4BRDTBRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0961618-B1 | 5-Pyrimidinyl-4-yl-Imidazole Derivate zur Behandlung von CSBP/RK/p38 vermittelten Erkrankungen | SMITHKLINE BEECHAM CORP (US) | 2004-08-04 | — | — | EP | claimed |