Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 9/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 4/20 | 0.38 |
| ▸ | HTR1B | P28222 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6579461 | 0.89 | ADRA2A (0.43) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6582501 | 0.88 | ADRA2A (0.39) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL4639205 | 0.81 | ADRA2A (0.47) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL4638692 | 0.77 | ADRA2A (0.44) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Acetic Acid SCHEMBL16699530 | 0.76 | ADRA2A (0.42) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7210059 | 0.76 | ADRA2A (0.46) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL7743446 | 0.76 | ADRA2A (0.52) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6579184 | 0.75 | ADRA2A (0.46) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL6579373 | 0.75 | — | — | |
| SCHEMBL6579433 | 0.73 | ADRA2A (0.64) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | claimed |
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6486190-B1 | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability | THE PROCTER & GAMBLE COMPANY | 2002-11-26 | — | — | US | disclosed |
| EP-1037887-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999026942-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |