Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.50 |
| ▸ | HTR1B | P28222 | 4/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 9/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.49 |
| ▸ | CFB | P00751 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 8/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581982 | 0.88 | HTR1D (0.54) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL6581944 | 0.83 | HTR1D (0.47) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL7665471 | 0.80 | HTR1D (0.39) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL6584946 | 0.78 | HTR1D (0.52) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL6579499 | 0.74 | PNP (0.34) | LMNA | |
| SCHEMBL10977629 | 0.73 | ADRA2C (0.67) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL6579623 | 0.71 | HTR1D (0.51) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL10979251 | 0.68 | HTR1D (0.71) | HTR1DHTR1BADRA2CADRA1ACFB | |
| SCHEMBL7086855 | 0.68 | HTR1D (0.48) | HTR1DHTR1BADRA2CADRA1ACFB | |
| Hydrochloric Acid SCHEMBL10973842 | 0.67 | HTR1D (0.69) | HTR1DHTR1BADRA2CADRA1ACFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | claimed |
| EP-1037887-B1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | PROCTER & GAMBLE (US) | 2004-07-14 | — | — | EP | disclosed |
| US-6486190-B1 | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability | THE PROCTER & GAMBLE COMPANY | 2002-11-26 | — | — | US | disclosed |
| EP-1037887-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999026942-A1 | 5-(2-IMIDAZOLINYLAMINO)-BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS .ALPHA.-ADRENOCEPTOR AGONISTS WITH IMPROVED METABOLIC STABILITY | THE PROCTER & GAMBLE COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |