Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 4/20 | 0.39 |
| ▸ | HTR1B | P28222 | 3/20 | 0.39 |
| ▸ | CFB | P00751 | 4/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | PTGIR | P43119 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581944 | 0.83 | HTR1D (0.47) | HTR1DHTR1BCFBADRA2CADRA1A | |
| SCHEMBL6579495 | 0.80 | HTR1D (0.50) | HTR1DHTR1BCFBADRA2CADRA1A | |
| SCHEMBL6579623 | 0.74 | HTR1D (0.51) | HTR1DHTR1BCFBADRA2CADRA1A | |
| SCHEMBL6583626 | 0.73 | PSMB8 (0.43) | MAPTTSHR | |
| SCHEMBL6581982 | 0.71 | HTR1D (0.54) | HTR1DHTR1BCFBADRA2CADRA1A | |
| SCHEMBL6579698 | 0.70 | TDP1 (0.44) | TSHR | |
| SCHEMBL6581945 | 0.63 | PSMB8 (0.32) | APOBEC3G | |
| SCHEMBL6583421 | 0.63 | PSMB8 (0.39) | APOBEC3G | |
| SCHEMBL7665475 | 0.61 | TYMS (0.33) | — | |
| SCHEMBL6583417 | 0.60 | MEN1 (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486190-B1 | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as .alpha.-adrenoceptor agonists with improved metabolic stability | THE PROCTER & GAMBLE COMPANY | 2002-11-26 | — | — | US | disclosed |