SCHEMBL6579784

SCHEMBL6579784

COc1ccccc1C(=O)c1nccn1CC(CCO)c1ccc(Cl)c(Cl)c1

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ESRRA P11474 1/20 0.38
KMT2A Q03164 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
KCNH2 Q12809 1/20 0.36
TACR2 P21452 5/20 0.35
TACR1 P25103 2/20 0.35
RORB Q92753 2/20 0.35
RORC P51449 1/20 0.35
BCL2L11 O43521 1/20 0.35
BCL2L1 Q07817 1/20 0.35
MCL1 Q07820 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
WDR5 P61964 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6582820 0.88 ESRRA (0.35) ESRRAKMT2ANPSR1CYP3A4CYP2D6
SCHEMBL6579045 0.84 RORC (0.41) TACR2RORCWDR5
SCHEMBL6579428 0.82 SLC6A3 (0.37) SLC6A3TACR2TACR1
SCHEMBL6577365 0.80 TACR2 (0.33) TACR2TACR1
SCHEMBL8142664 0.80 TACR2 (0.33) TACR2TACR1
SCHEMBL6579463 0.80 TACR2 (0.33) TACR2TACR1
SCHEMBL6579685 0.80 HTT (0.34) KMT2ATACR2WDR5
SCHEMBL6579564 0.80 NPC1 (0.35) KMT2ATACR2
SCHEMBL6577348 0.78 TACR2 (0.33) TACR2TACR1
SCHEMBL6579391 0.78 TACR2 (0.32) TACR2TACR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0994876-B1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LTD (GB) 2004-09-08 EP disclosed
US-6380396-B1 CHEMICAL INTERMEDIATES FOR ANTIINFLAMMATORY AGENTS PFIZER INC. 2002-04-30 US disclosed
US-6207678-B1 USED FOR TREATING INFLAMMATORY DISEASE SUCH AS ARTHRITIS, PSORIASIS, ASTHMA OR INFLAMMATORY BOWEL DISEASE, CENTRAL NERVOUS SYSTEM DISORDER SUCH AS ANXIETY, DEPRESSION, DEMENTIA OR PSYCHOSIS, GASTROINTESTINAL DISORDERS PFIZER INC 2001-03-27 US disclosed
EP-0994876-A1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS Pfizer Limited (GB) 2000-04-26 EP disclosed
WO-1998057972-A1 QUATERNARY AMMONIUM COMPOUNDS AS TACHYKININ ANTAGONISTS PFIZER LIMITED (GB) 1998-12-23 WO disclosed