Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 16/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 8/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580540 | 0.89 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1D | |
| SCHEMBL6577905 | 0.89 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL6579957 | 0.89 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL14416822 | 0.79 | HTR1A (0.78) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL6752779 | 0.77 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL6577695 | 0.77 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL6582012 | 0.77 | ADRA1B (1.00) | HTR1AADRA1BADRA1AADRA1D | |
| SCHEMBL6752801 | 0.77 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| SCHEMBL6751064 | 0.76 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 | |
| Bmy-7378 SCHEMBL6017145 | 0.76 | HTR1A (1.00) | HTR1AADRA1BADRA1AADRA1DDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | claimed |
| EP-1200406-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005765-A1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA SPA (IT) | 2001-01-25 | — | — | WO | claimed |
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |