Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE6D | O43924 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580208 | 0.94 | EDNRB (0.45) | EDNRBEDNRATP53BRS3 | |
| SCHEMBL8431736 | 0.89 | BRS3 (0.42) | EDNRAMAPTBRS3LMNAKMT2A | |
| SCHEMBL8329557 | 0.89 | MEN1 (0.39) | EDNRBEDNRATP53MAPTPOLB | |
| SCHEMBL8434942 | 0.88 | BRS3 (0.42) | BRS3LMNAKMT2A | |
| SCHEMBL8323946 | 0.88 | EDNRB (0.40) | EDNRBEDNRABRS3LMNA | |
| SCHEMBL6580124 | 0.85 | MEN1 (0.41) | EDNRBEDNRATP53MAPTBRS3 | |
| SCHEMBL8434873 | 0.84 | EDNRA (0.45) | EDNRBEDNRATP53MAPTBRS3 | |
| SCHEMBL6582508 | 0.84 | EDNRA (0.43) | EDNRBEDNRAKMT2A | |
| SCHEMBL7501396 | 0.82 | EDNRA (0.45) | EDNRBEDNRABRS3LMNAKMT2A | |
| SCHEMBL6580278 | 0.82 | EDNRA (0.45) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856509-A | HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1999-01-05 | — | — | US | disclosed |