Sugi Predict

Sugi Predict / Compounds / SCHEMBL658023

SCHEMBL658023

SCHEMBL658023

CCOC(=O)C=C(c1ccc(Br)cc1)c1ccc(Br)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ NPSR1 Q6W5P4 3/20 0.49
▸ LMNA P02545 3/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ S1PR4 O95977 1/20 0.49
▸ S1PR1 P21453 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ ALDH1A1 P00352 3/20 0.46
▸ HPGD P15428 2/20 0.46
▸ NHERF1 O14745 1/20 0.43
▸ PPARG P37231 1/20 0.42
▸ PPARD Q03181 1/20 0.42
▸ PPARA Q07869 1/20 0.42
▸ MAOB P27338 1/20 0.42
▸ CYP1A2 P05177 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ HTT P42858 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744978 0.94 NPC1 (0.48) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL1744974 0.94 NPC1 (0.48) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL1744976 0.94 NPC1 (0.48) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL3000190 0.87 ALDH1A1 (0.44) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL2192538 0.85 KMT2A (0.47) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL2192534 0.85 KMT2A (0.47) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL2192541 0.85 KMT2A (0.47) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL3012942 0.84 ATM (0.47) MAPTLMNAMAPK1ALDH1A1HPGD
SCHEMBL1144240 0.83 MAPT (0.46) MAPTKMT2ANPSR1LMNAMEN1
SCHEMBL1144241 0.83 MAPT (0.46) MAPTKMT2ANPSR1LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100197950-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HIGH POINT PHARMACEUTICALS, LLC 2010-08-05 — — US claimed
EP-2029507-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES High Point Pharmaceuticals, LLC (US) 2009-03-04 — — EP claimed
WO-2007141295-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HIGH POINT PHARMACEUTICALS, LLC (US) 2007-12-13 — — WO claimed
US-20120046350-A1 NOVEL COMPOUNDS, THEIR PREPARATION AND USE HIGH POINT PHARMACEUTICALS, LLC (US) 2012-02-23 — — US disclosed
US-20100197950-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HIGH POINT PHARMACEUTICALS, LLC 2010-08-05 — — US disclosed
US-20100197950-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HIGH POINT PHARMACEUTICALS, LLC 2010-08-05 — — US disclosed
US-20100197950-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HIGH POINT PHARMACEUTICALS, LLC 2010-08-05 — — US disclosed
EP-1558572-B1 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS HIGH POINT PHARMACEUTICALS LLC (US) 2010-06-30 — — EP disclosed
EP-1558571-B1 NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES HIGH POINT PHARMACEUTICALS LLC (US) 2010-06-02 — — EP disclosed
US-7709528-B2 Compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC (US) 2010-05-04 — — US disclosed
EP-2029507-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES High Point Pharmaceuticals, LLC (US) 2009-03-04 — — EP disclosed
US-20050070583-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2005-03-31 — — US disclosed
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 — — US disclosed
US-20040143006-A1 Novel compounds, their preparation and use HIGH POINT PHARMACEUTICALS, LLC 2004-07-22 — — US disclosed
WO-2004037776-A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS NOVO NORDISK A/S (DK) 2004-05-06 — — WO disclosed
WO-2004037775-A1 NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES NOVO NORDISK A/S (DK) 2004-05-06 — — WO disclosed
EP-1414778-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2004-05-06 — — EP disclosed
WO-2004022533-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR THERAPEUTICAL USE NOVO NORDISK A/S (DK) 2004-03-18 — — WO disclosed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 — — US disclosed
WO-2003011807-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. NOVO NORDISK A/S (DK) 2003-02-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050070583-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA MAPT 3498/4885KMT2A 4570/4885NPSR1 964/4885
US-20030139473-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA MAPT 3939/4885KMT2A 4575/4885NPSR1 696/4885
US-20040143006-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA MAPT 3939/4885KMT2A 4575/4885NPSR1 696/4885
US-20120046350-A1 NOVEL COMPOUNDS, THEIR PREPARATION AND USE PPARG, PPARD, PPARA MAPT 3498/4885KMT2A 4570/4885NPSR1 964/4885
US-20100197950-A1 PROCESS FOR PREPARING PHENOXY ACETIC ACID DERIVATIVES HAAO, HPD, PAH MAPT 1239/4885KMT2A 395/4885NPSR1 3077/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.