Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 15/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 11/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580269 | 0.98 | HTR1A (0.48) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL9034075 | 0.87 | HTR1A (0.50) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL7304949 | 0.85 | HTR1A (0.52) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL9035109 | 0.84 | HTR1A (0.51) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL11608413 | 0.81 | HTR1A (0.47) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL8943556 | 0.78 | HTR1A (0.48) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL12600977 | 0.78 | HTR1A (0.48) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL9386416 | 0.78 | HTR1A (0.48) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL6751068 | 0.78 | HTR1A (0.49) | HTR1AADRA1BADRA1ADRD2ADRA1D | |
| SCHEMBL14359379 | 0.78 | HTR1A (0.51) | HTR1AADRA1BADRA1ADRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200406-B1 | CYCLIC AMIDES AND IMIDES HAVING SELECTIVE ANTAGONIST ACTIVITY AT ALPHA-1D ADRENERGIC RECEPTOR | RECORDATI CHEM PHARM (IT) | 2004-11-24 | — | — | EP | disclosed |