Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035109 | 0.98 | HTR1A (0.51) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL9034075 | 0.95 | HTR1A (0.50) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL6580269 | 0.87 | HTR1A (0.48) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL6580422 | 0.85 | HTR1A (0.47) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL10469887 | 0.83 | HTR1A (0.38) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL12557639 | 0.82 | HTR1A (0.52) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL18463363 | 0.82 | HTR1A (0.52) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL9778481 | 0.82 | HTR1A (0.52) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL7410588 | 0.82 | HTR1A (0.55) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 | |
| SCHEMBL10469856 | 0.81 | HTR1A (0.39) | HTR1AALDH1A1ADRA1AADRA1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395192-A2 | Process for the preparation of 8-(4-(4-pyrimidin-2-yl-piperazinyl)-butyl)-8-aza-spiro(4.5)decane-7,9-dione (buspiron) | ALKALOIDA VEGYESZETI GYAR (HU) | 1990-10-31 | — | — | EP | claimed |
| EP-0422134-B1 | 5-HT SELECTIVE AGENTS | ABBOTT LAB (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0571243-B1 | Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| EP-0515462-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1995-05-31 | — | — | EP | disclosed |
| US-5420150-A | Antidepressants and treatment of anxiety | GUILLAUMET GERALD (FR) | 1995-05-30 | — | — | US | disclosed |
| US-5397783-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1995-03-14 | — | — | US | disclosed |
| US-5395841-A | 4-benzylpiperidines for treating phychosis | FERRER INTERNACIONAL, S.A. (ES) | 1995-03-07 | — | — | US | disclosed |
| US-5389668-A | Thiochroman compounds | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385930-A | Treating central nervous system disorders like anxiety and depression | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| US-5376661-A | Psychological disorders | ADIR ET COMPAGNIE (FR) | 1994-12-27 | — | — | US | disclosed |
| WO-1991012252-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-08-22 | — | — | WO | disclosed |
| WO-1991004973-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-04-18 | — | — | WO | disclosed |
| EP-0422134-A1 | 5-HT SELECTIVE AGENTS. | ABBOTT LAB (US) | 1991-04-17 | — | — | EP | disclosed |
| EP-0395192-A2 | Process for the preparation of 8-(4-(4-pyrimidin-2-yl-piperazinyl)-butyl)-8-aza-spiro(4.5)decane-7,9-dione (buspiron) | ALKALOIDA VEGYESZETI GYAR (HU) | 1990-10-31 | — | — | EP | disclosed |
| WO-1990006927-A1 | 5-HT SELECTIVE AGENTS | ABBOTT LABORATORIES (US) | 1990-06-28 | — | — | WO | disclosed |
| US-4581357-A | Antipsychotic 5-fluoro-pyrimidin-2-yl piperazine compound | MEAD JOHNSON & COMPANY (US) | 1986-04-08 | — | — | US | disclosed |
| US-4452799-A | NEUROLEPTIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1984-06-05 | — | — | US | disclosed |
| US-4411901-A | ANTIPSYCHOTICS | MEAD JOHNSON & COMPANY (US) | 1983-10-25 | — | — | US | disclosed |
| US-4320131-A | N-[(4-Phenyl-1,2,3,6-tetrahydropyridin-1-yl)alkylene]azaspiroalkanediones and N-[(4-hydroxy-4-phenylpiperidin-1-yl)alkylene]azaspiroalkanediones | MEAD JOHNSON & COMPANY (US) | 1982-03-16 | — | — | US | disclosed |
| US-4305944-A | TRANQUILIZERS, NEUROLEPTIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1981-12-15 | — | — | US | disclosed |