Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6581027 | 0.99 | HTR7 (0.46) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| SCHEMBL6578288 | 0.90 | S1PR1 (0.47) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6581197 | 0.89 | S1PR1 (0.53) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6578720 | 0.89 | S1PR1 (0.46) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| SCHEMBL6581627 | 0.89 | S1PR1 (0.42) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6581348 | 0.88 | S1PR1 (0.41) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| SCHEMBL6578750 | 0.87 | NR1H2 (0.47) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6578160 | 0.86 | NR1H2 (0.46) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL6580524 | 0.82 | NR1H2 (0.58) | HTR7ADORA2AADORA1NR1H2NR1H3 | |
| SCHEMBL6578503 | 0.82 | ADORA2A (0.62) | HTR7ADORA2AADORA1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | claimed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | claimed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | claimed |
| EP-1070708-B1 | Triazole derivatives | HOFFMANN LA ROCHE (CH) | 2004-01-14 | — | — | EP | disclosed |
| US-6265426-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2001-07-24 | — | — | US | disclosed |
| EP-1070708-A1 | Triazole and imidazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-24 | — | — | EP | disclosed |