Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583651 | 1.00 | HTR2A (0.50) | HTR2AHTR2CP2RX7GRIN2BDHFR | |
| SCHEMBL4334602 | 0.81 | HTR2C (0.50) | HTR2AHTR2CP2RX7GRIN2BDHFR | |
| SCHEMBL30098906 | 0.81 | DHFR (0.43) | HTR2AHTR2CP2RX7GRIN2BDHFR | |
| SCHEMBL6580104 | 0.78 | HTR2C (0.55) | HTR2AHTR2CGRIN2BDHFRPRMT5 | |
| SCHEMBL6580004 | 0.78 | HTR2C (0.55) | HTR2AHTR2CGRIN2BDHFRPRMT5 | |
| SCHEMBL30119624 | 0.73 | CDK4 (0.55) | HTR2AHTR2CDHFRHTR6LMNA | |
| SCHEMBL15380532 | 0.73 | DHFR (0.51) | GRIN2BDHFRMAPTMEN1LMNA | |
| SCHEMBL408456 | 0.73 | CDK4 (0.55) | HTR2AHTR2CDHFRHTR6LMNA | |
| SCHEMBL10311225 | 0.73 | HTR2C (0.63) | HTR2AHTR2CP2RX7PRMT5SLC6A4 | |
| SCHEMBL14353267 | 0.73 | DHFR (0.39) | HTR2CGRIN2BDHFRPRMT5HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075471-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-11-17 | — | — | EP | disclosed |
| CN-1144800-C | Indolyl derivatives as 5-hydroxytryptamine drugs | — | 2004-04-07 | — | — | CN | disclosed |
| CN-1307574-A | Indolyl derivatives as 5-hydroxytryptamine drugs | AMERICAN HOME PROD (US) | 2001-08-08 | — | — | CN | disclosed |
| US-6204274-B1 | TREAT CENTRAL NERVOUS SYSTEM DISORDERS, SUCH AS DEPRESSION AND ANXIETY AND OTHER CONDITIONS FOR WHICH SEROTONIN REUPTAKE INHIBITORS ARE USED. | AMERICAN HOME PRODUCTS CORPORATION | 2001-03-20 | — | — | US | disclosed |
| EP-1075471-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999055694-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |