Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580104 | 1.00 | HTR2C (0.55) | HTR2CPRMT5HTR6DHFRFABP4 | |
| SCHEMBL14353267 | 0.83 | DHFR (0.39) | HTR2CPRMT5HTR6DHFRGRIN2B | |
| SCHEMBL4326536 | 0.80 | HTR6 (0.46) | HTR2CHTR6DHFR | |
| SCHEMBL6583651 | 0.78 | HTR2A (0.50) | HTR2CPRMT5HTR6DHFRFABP4 | |
| SCHEMBL30098906 | 0.78 | DHFR (0.43) | HTR2CHTR6DHFRALDH1A1TSHR | |
| SCHEMBL6581230 | 0.78 | HTR2A (0.50) | HTR2CPRMT5HTR6DHFRFABP4 | |
| SCHEMBL4334602 | 0.78 | HTR2C (0.50) | HTR2CPRMT5HTR6DHFRSMN1; SMN2 | |
| SCHEMBL13228252 | 0.77 | HTR2C (0.65) | HTR2CPRMT5HTR6FABP4KDM4E | |
| SCHEMBL25010270 | 0.73 | HTR2C (0.60) | HTR2CPRMT5HTR6FABP4ALDH1A1 | |
| SCHEMBL12543673 | 0.73 | HTR2C (0.60) | HTR2CPRMT5HTR6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1075471-B1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | WYETH CORP (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6204274-B1 | TREAT CENTRAL NERVOUS SYSTEM DISORDERS, SUCH AS DEPRESSION AND ANXIETY AND OTHER CONDITIONS FOR WHICH SEROTONIN REUPTAKE INHIBITORS ARE USED. | AMERICAN HOME PRODUCTS CORPORATION | 2001-03-20 | — | — | US | disclosed |
| EP-1075471-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999055694-A1 | INDOLYL DERIVATIVES AS SEROTONERGIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |