Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ANPEP | P15144 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468849 | 0.90 | NPC1 (0.67) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL9453218 | 0.89 | MEN1 (0.57) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL9566664 | 0.88 | NPC1 (0.65) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL9358156 | 0.86 | ALDH1A1 (0.64) | ALDH1A1NPC1TSHRRAB9AMEN1 | |
| SCHEMBL9573079 | 0.85 | ALDH1A1 (0.71) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL6578947 | 0.83 | ALDH1A1 (0.73) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL17946142 | 0.83 | ALDH1A1 (0.60) | ALDH1A1NPC1TSHRRAB9AMEN1 | |
| SCHEMBL726842 | 0.83 | KDM4E (0.59) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL4782142 | 0.83 | ALDH1A1 (0.72) | ALDH1A1NPC1TSHRCASP1RAB9A | |
| SCHEMBL2553055 | 0.83 | KDM4E (0.68) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192131-B1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER LAMBERT CO (US) | 2004-08-04 | — | — | EP | disclosed |
| EP-1192131-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076969-A1 | METHOD OF INHIBITING AMYLOID PROTEIN AGGREGATION AND IMAGING AMYLOID DEPOSITS USING ISOINDOLINE DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |