Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3751072 | 0.79 | BRD4 (0.53) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL21105084 | 0.78 | PTGS1 (0.55) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL15270257 | 0.77 | ESR1 (0.50) | ALDH1A1MAPTSMN1; SMN2PTGS1DUSP3 | |
| SCHEMBL19916055 | 0.77 | HRH3 (0.42) | ALDH1A1SMN1; SMN2KDM4ETP53HSD17B10 | |
| SCHEMBL8376901 | 0.76 | PTPN1 (0.44) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL8375545 | 0.76 | MEN1 (0.49) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL7050224 | 0.76 | ALDH1A1 (0.46) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL8375701 | 0.76 | PTPN1 (0.44) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 | |
| SCHEMBL4076415 | 0.76 | PTPN1 (0.67) | PTPN1ALDH1A1MAPTPTGS1DUSP3 | |
| SCHEMBL12000499 | 0.76 | PTGS1 (0.43) | PTPN1ALDH1A1MAPTSMN1; SMN2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737680-B1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | SOLVAY PHARM GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-0737680-A1 | (Phenylalkylaminoalkyloxyl)-hetero-aryl compounds, processes and intermediates for their preparation and medicaments containing these compounds | Kali-Chemie Pharma GmbH (DE) | 1996-10-16 | — | — | EP | disclosed |
| US-5321037-A | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | SANKYO COMPANY, LIMITED (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0335723-B1 | ISOXAZOLE DERIVATIVES FOR USE AS CEREBRO-ACTIVE DRUGS AND CENTRAL MUSCLE RELAXANTS | Sankyo Company Limited (JP) | 1991-12-04 | — | — | EP | disclosed |
| EP-0335723-A1 | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | Sankyo Company Limited (JP) | 1989-10-04 | — | — | EP | disclosed |