Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.39 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20678523 | 0.78 | PTGS1 (0.47) | PTPN1NR1H4ALDH1A1TP53HSD17B10 | |
| SCHEMBL8376901 | 0.76 | PTPN1 (0.44) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL7050224 | 0.76 | ALDH1A1 (0.46) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL3925819 | 0.76 | BRD4 (0.50) | PTPN1ALDH1A1PTGS1SMN1; SMN2NPC1 | |
| SCHEMBL8375545 | 0.76 | MEN1 (0.49) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL6581665 | 0.76 | PTPN1 (0.44) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL8375814 | 0.72 | MEN1 (0.42) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL8376510 | 0.72 | PTPN1 (0.41) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL7375744 | 0.72 | NOTUM (0.42) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 | |
| SCHEMBL8378821 | 0.71 | S1PR1 (0.41) | PTPN1ALDH1A1IP6K1IP6K3IP6K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| CN-1216986-A | Isoxazole derivatives | SANKYO CO (JP) | 1999-05-19 | — | — | CN | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |