SCHEMBL6581722

SCHEMBL6581722

CCOc1ccc(-c2nc(-c3cccc(CN4CCCC4)c3)n[nH]2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 1/20 0.63
ADORA1 P30542 1/20 0.63
S1PR1 P21453 2/20 0.54
CNR1 P21554 3/20 0.52
CNR2 P34972 3/20 0.52
HRH3 Q9Y5N1 1/20 0.50
DRD2 P14416 4/20 0.45
DRD4 P21917 2/20 0.45
DRD3 P35462 2/20 0.45
KDM4E B2RXH2 2/20 0.45
NR1H2 P55055 1/20 0.45
NR1H3 Q13133 1/20 0.45
MAPK1 P28482 3/20 0.43
LMNA P02545 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CHRM3 P20309 1/20 0.43
PKM P14618 1/20 0.43
HTR1A P08908 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6578605 0.99 ADORA2A (0.62) ADORA2AADORA1S1PR1CNR1CNR2
SCHEMBL6583869 0.89 ADORA2A (0.65) ADORA2AADORA1S1PR1CNR1CNR2
Hydrochloric Acid SCHEMBL6578937 0.88 ADORA2A (0.64) ADORA2AADORA1S1PR1CNR1CNR2
Hydrochloric Acid SCHEMBL6581231 0.88 ADORA2A (0.63) ADORA2AADORA1S1PR1CNR1CNR2
SCHEMBL6578715 0.87 ADORA2A (0.62) ADORA2AADORA1CNR1CNR2DRD2
Hydrochloric Acid SCHEMBL6578576 0.86 ADORA2A (0.61) ADORA2AADORA1S1PR1CNR1CNR2
SCHEMBL6582919 0.84 ADORA2A (0.62) ADORA2AADORA1S1PR1CNR1CNR2
Hydrochloric Acid SCHEMBL6582805 0.84 ADORA2A (0.69) ADORA2AADORA1S1PR1CNR1CNR2
Hydrochloric Acid SCHEMBL6580998 0.84 ADORA2A (0.61) ADORA2AADORA1S1PR1CNR1CNR2
Hydrochloric Acid SCHEMBL6581094 0.84 ADORA2A (0.61) ADORA2AADORA1S1PR1CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP claimed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US claimed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP claimed
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP disclosed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US disclosed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP disclosed