SCHEMBL6582919

SCHEMBL6582919

FC(F)Oc1ccc(-c2nc(-c3cccc(CN4CCCC4)c3)n[nH]2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.62
ADORA1 P30542 2/20 0.62
HRH3 Q9Y5N1 1/20 0.44
S1PR1 P21453 1/20 0.42
CNR2 P34972 4/20 0.42
CNR1 P21554 3/20 0.42
NR1H2 P55055 1/20 0.41
NR1H3 Q13133 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
DRD2 P14416 1/20 0.40
DRD4 P21917 1/20 0.40
DRD3 P35462 1/20 0.40
PARP1 P09874 2/20 0.39
ALDH1A1 P00352 3/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 2/20 0.39
ATAD2 Q6PL18 1/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6581094 0.99 ADORA2A (0.61) ADORA2AADORA1HRH3S1PR1CNR2
Hydrochloric Acid SCHEMBL6580700 0.91 ADORA2A (0.61) ADORA2AADORA1HRH3S1PR1CNR2
Hydrochloric Acid SCHEMBL6578576 0.89 ADORA2A (0.61) ADORA2AADORA1HRH3S1PR1CNR2
SCHEMBL6583869 0.86 ADORA2A (0.65) ADORA2AADORA1HRH3S1PR1CNR2
Hydrochloric Acid SCHEMBL6578937 0.85 ADORA2A (0.64) ADORA2AADORA1HRH3S1PR1CNR2
Hydrochloric Acid SCHEMBL6580998 0.85 ADORA2A (0.61) ADORA2AADORA1HRH3S1PR1CNR2
SCHEMBL6581722 0.84 ADORA2A (0.63) ADORA2AADORA1HRH3S1PR1CNR2
Hydrochloric Acid SCHEMBL6581231 0.84 ADORA2A (0.63) ADORA2AADORA1HRH3S1PR1CNR2
SCHEMBL6578715 0.84 ADORA2A (0.62) ADORA2AADORA1CNR2CNR1NR1H2
Hydrochloric Acid SCHEMBL6578493 0.84 ADORA2A (0.67) ADORA2AADORA1HRH3S1PR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP claimed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US claimed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP claimed
EP-1070708-B1 Triazole derivatives HOFFMANN LA ROCHE (CH) 2004-01-14 EP disclosed
US-6265426-B1 CENTRAL NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. 2001-07-24 US disclosed
EP-1070708-A1 Triazole and imidazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2001-01-24 EP disclosed