Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581743 | 1.00 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583752 | 0.87 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588337 | 0.85 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7963965 | 0.83 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916015 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7916020 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585932 | 0.80 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585936 | 0.80 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6584136 | 0.79 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583751 | 0.78 | SIGMAR1 (0.51) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6274584-B1 | PEPTIDE DERIVATIVES; BIOAVAILABILITY; ENZYME RESISTANCE; MILK AND WOOL PRODUCTION | NOVO NORDISK A/S (DK) | 2001-08-14 | — | — | US | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| US-6127354-A | FOR TREATMENT OF GROWTH DISORDERS OR TO STIMULATE PRODUCTION OF WOOL OR MILK | NOVO NORDISK A/S (DK) | 2000-10-03 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |
| US-5922770-A | NOVEL COMPOUNDS THAT STIMULATE THE RELEASE OF GROWTH HORMONE FROM THE PITUITARY | NOVO NORDISK A/S (DK) | 1999-07-13 | — | — | US | disclosed |
| US-4464299-A | Antibacterial carbapenem compounds | SHIONOGI & CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| US-4440683-A | Cyclization to form cephem ring and azetidinone intermediates therefor | SHIONOGI & CO., LTD. (JP) | 1984-04-03 | — | — | US | disclosed |
| US-4346218-A | DECYCLIZATION OF AN AZETIDINOTHIAZOLINE | SHIONOGI & CO., LTD. (JP) | 1982-08-24 | — | — | US | disclosed |
| US-RE30053-E | PG-type, 1,9-lactones | THE UPJOHN COMPANY (US) | 1979-07-24 | — | — | US | disclosed |
| US-4079181-A | INTERMEDIATES FOR 3-HYDROXY-3-CEPHEM COMPOUNDS | SHIONOGI & CO., LTD. (JA) | 1978-03-14 | — | — | US | disclosed |
| US-4049678-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1977-09-20 | — | — | US | disclosed |
| US-4049648-A | PROSTAGLANDINS | THE UPJOHN COMPANY (US) | 1977-09-20 | — | — | US | disclosed |