Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | PTAFR | P25105 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583752 | 0.89 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583426 | 0.88 | PDE4B (0.51) | PDE4BPDE4D | |
| SCHEMBL6584261 | 0.87 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4DPTAFR | |
| SCHEMBL6582719 | 0.87 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6582911 | 0.87 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583040 | 0.86 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11430670 | 0.86 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DACHE | |
| SCHEMBL6583108 | 0.85 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588337 | 0.85 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6583656 | 0.85 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DPTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |