Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 18/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 18/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582946 | 1.00 | MTNR1A (0.62) | MTNR1AMTNR1BPIM1PIM3PIM2 | |
| SCHEMBL1285561 | 1.00 | MTNR1A (0.62) | MTNR1AMTNR1BPIM1PIM3PIM2 | |
| SCHEMBL6584385 | 0.81 | ADRB1 (0.56) | — | |
| SCHEMBL6584380 | 0.81 | ADRB1 (0.56) | — | |
| SCHEMBL1285441 | 0.78 | MTNR1A (0.40) | MTNR1AMTNR1BPIM1PIM3PIM2 | |
| SCHEMBL6583239 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL6583235 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL6585112 | 0.77 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL6583029 | 0.75 | MTNR1A (1.00) | MTNR1AMTNR1B | |
| SCHEMBL6582325 | 0.75 | MTNR1A (1.00) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189900-B1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1189900-A4 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2002-07-31 | — | — | EP | disclosed |
| EP-1189900-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-03-27 | — | — | EP | disclosed |
| US-6211225-B1 | SLEEP DISORDERS AND CIRCADIAN RHYTHM DISORDERS | BRISTOL-MEYERS SQUIBB | 2001-04-03 | — | — | US | disclosed |
| WO-2001002392-A1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-01-11 | — | — | WO | disclosed |