Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.49 |
| ▸ | PDE4A | P27815 | 6/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.49 |
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | PDE1A | P54750 | 1/20 | 0.48 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584795 | 0.96 | SETD7 (0.50) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6581707 | 0.90 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6583317 | 0.89 | PGR (0.49) | PGRMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL6579233 | 0.89 | PGR (0.49) | PGRMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL6584543 | 0.89 | PDE5A (0.52) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6582350 | 0.88 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6605978 | 0.88 | PDE5A (0.51) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| Dimethylamine SCHEMBL6763137 | 0.88 | PGR (0.47) | PGRMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL6583352 | 0.87 | PGR (0.50) | PGRMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL6584769 | 0.87 | PGR (0.50) | PGRMEN1KMT2AALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194411-B1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-06-16 | — | — | EP | disclosed |
| US-6696446-B1 | HETEROCYLCIC AMIDES SUCH AS N-(4-(3-(3-(3-ETHOXY-4-METHOXY PHENYL)-1,4,5,6-TETRAHYDRO-1-PYRIDAZINYLCARBONYL)PHENYLAMINO -CARBONYL)PHENYL)-4-NITROBENZAMIDE, SUED AS PHOSPHODIESTERASE INHIBITORSFOR PROPHYLAXIS OF ALLERGIES OR ASTHMA | MERCK PATENT GMBH (DE) | 2004-02-24 | — | — | US | disclosed |
| EP-1194411-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001004099-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | disclosed |