Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 9/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.51 |
| ▸ | PDE4A | P27815 | 8/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.51 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584543 | 0.91 | PDE5A (0.52) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6582350 | 0.91 | PDE4D (0.49) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6605978 | 0.90 | PDE5A (0.51) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6581786 | 0.90 | PDE4B (0.49) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6584795 | 0.89 | SETD7 (0.50) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6583492 | 0.88 | ALDH1A1 (0.51) | ALDH1A1LMNAPKMNPSR1PGR | |
| SCHEMBL6602063 | 0.88 | PDE4B (0.52) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6607012 | 0.88 | PDE4B (0.52) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL6600966 | 0.87 | PDE4A (0.48) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL145758 | 0.87 | PDE5A (0.49) | PDE4DPDE4BPDE4APDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194411-B1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-06-16 | — | — | EP | disclosed |
| US-6696446-B1 | HETEROCYLCIC AMIDES SUCH AS N-(4-(3-(3-(3-ETHOXY-4-METHOXY PHENYL)-1,4,5,6-TETRAHYDRO-1-PYRIDAZINYLCARBONYL)PHENYLAMINO -CARBONYL)PHENYL)-4-NITROBENZAMIDE, SUED AS PHOSPHODIESTERASE INHIBITORSFOR PROPHYLAXIS OF ALLERGIES OR ASTHMA | MERCK PATENT GMBH (DE) | 2004-02-24 | — | — | US | disclosed |
| EP-1194411-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001004099-A1 | BENZOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | disclosed |