Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21724826 | 0.77 | SIRT2 (0.63) | SIRT2PIK3C3ALDH1A1PDCD1CD274 | |
| SCHEMBL6582515 | 0.77 | PDCD1 (0.42) | SIRT2ALDH1A1PDCD1CD274KDM4E | |
| SCHEMBL7014444 | 0.73 | PDCD1 (0.42) | ALDH1A1PDCD1CD274KDM4EHPGD | |
| SCHEMBL7021149 | 0.72 | HDAC3 (0.43) | ALDH1A1PDCD1CD274HPGDLMNA | |
| SCHEMBL6374412 | 0.72 | ALDH1A1 (0.44) | SIRT2PIK3C3ALDH1A1PDCD1CD274 | |
| SCHEMBL6374279 | 0.71 | SIRT2 (0.56) | SIRT2PIK3C3ALDH1A1KDM4EHPGD | |
| SCHEMBL4839328 | 0.71 | SIRT2 (0.75) | SIRT2PIK3C3ALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL5243116 | 0.70 | SIRT2 (0.73) | SIRT2PIK3C3ALDH1A1KDM4EHPGD | |
| SCHEMBL28170369 | 0.68 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDNPSR1HSD17B10 | |
| SCHEMBL16404476 | 0.68 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDNPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458688-A1 | QUINAZOLINONE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055865-A1 | QUINAZOLINONE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-10 | — | — | WO | disclosed |