Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582578 | 0.77 | SIRT2 (0.43) | PDCD1CD274TP53KDM4EALDH1A1 | |
| SCHEMBL6373258 | 0.72 | PARP1 (0.44) | PDCD1CD274TP53NPC1RAB9A | |
| SCHEMBL7014444 | 0.70 | PDCD1 (0.42) | PDCD1CD274NPC1RAB9AKDM4E | |
| SCHEMBL7021149 | 0.69 | HDAC3 (0.43) | PDCD1CD274ALDH1A1HPGD | |
| SCHEMBL31751997 | 0.68 | PDCD1 (0.51) | PDCD1CD274TP53NPC1RAB9A | |
| SCHEMBL25334138 | 0.62 | F2 (0.48) | ALDH1A1 | |
| SCHEMBL21446872 | 0.62 | PDCD1 (1.00) | PDCD1CD274NPC1RAB9AALDH1A1 | |
| SCHEMBL786246 | 0.61 | PDCD1 (0.81) | PDCD1CD274TP53NPC1RAB9A | |
| SCHEMBL11284668 | 0.60 | PDCD1 (0.64) | PDCD1CD274NPC1RAB9AKDM4E | |
| SCHEMBL1409830 | 0.59 | KDM4E (0.64) | PDCD1CD274TP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458688-A1 | QUINAZOLINONE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055865-A1 | QUINAZOLINONE DERIVATIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-07-10 | — | — | WO | disclosed |