SCHEMBL658265

SCHEMBL658265

O=C(CC(c1ccccc1)C(C(=O)O)C(=O)O)c1ccc(Cl)cc1

nearest known ligand 0.72

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDPK1 O15530 5/20 0.72
POLB P06746 2/20 0.54
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
MAPT P10636 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
MMP2 P08253 3/20 0.50
MMP3 P08254 3/20 0.50
MMP9 P14780 3/20 0.50
MMP13 P45452 2/20 0.50
MMP1 P03956 1/20 0.50
MMP8 P22894 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
TSHR P16473 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2141563 0.94 PDPK1 (0.63) PDPK1POLBKMT2AMEN1MAPT
SCHEMBL656058 0.93 PDPK1 (0.62) PDPK1POLBKMT2AMEN1L3MBTL1
SCHEMBL2141566 0.88 PDPK1 (0.78) PDPK1KMT2AMEN1MAPTL3MBTL1
SCHEMBL657707 0.88 PDPK1 (0.56) PDPK1POLBKMT2AMEN1L3MBTL1
SCHEMBL657479 0.86 PDPK1 (0.56) PDPK1POLBKMT2AMEN1MAPT
SCHEMBL657492 0.86 PDPK1 (0.76) PDPK1POLBKMT2AMEN1L3MBTL1
SCHEMBL2142802 0.86 PDPK1 (0.55) PDPK1POLBKMT2AMEN1L3MBTL1
SCHEMBL10256955 0.86 POLB (0.72) PDPK1POLBKMT2AMEN1MAPT
SCHEMBL657374 0.86 KMT2A (0.72) PDPK1POLBKMT2AMEN1L3MBTL1
SCHEMBL1991487 0.84 PDPK1 (0.55) PDPK1POLBKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 US claimed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 EP claimed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO claimed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP claimed
US-20260061069-A1 SIZE-TUNABLE SYNTHETIC PARTICLES FOR IMMUNE CELL ACTIVATION SLINGSHOT BIOSCIENCES INC (US) 2026-03-05 US disclosed
US-20250389633-A1 SYNTHETIC HUMAN CELL MIMIC PARTICLE FOR CYTOMETRIC OR COULTER DEVICE SLINGSHOT BIOSCIENCES, INC. (US) 2025-12-25 US disclosed
US-12461007-B2 CD34 stem cell mimics SLINGSHOT BIOSCIENCES, INC. (US) 2025-11-04 US disclosed
EP-3256850-B1 HYDROGEL PARTICLES WITH TUNABLE OPTICAL PROPERTIES AND METHODS FOR USING THE SAME SLINGSHOT BIOSCIENCES INC (US) 2025-07-09 EP disclosed
US-12352679-B2 Synthetic human cell mimic particle for cytometric or coulter device SLINGSHOT BIOSCIENCES, INC. (US) 2025-07-08 US disclosed
US-20250164373-A1 SYNTHETIC HUMAN CELL MIMIC PARTICLE FOR CYTOMETRIC OR COULTER DEVICE SLINGSHOT BIOSCIENCES, INC. (US) 2025-05-22 US disclosed
WO-2025090968-A1 HYDROGEL CELL MIMICS WITH SUBCELLULAR FEATURES SLINGSHOT BIOSCIENCES, INC. (US) 2025-05-01 WO disclosed
US-12282021-B2 Stratification of acute myeloid leukaemia patients for sensitivity to kinase pathway inhibitor therapy KINOMICA LIMITED (GB) 2025-04-22 US disclosed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 EP disclosed
US-20110054190-A1 CATALYST AND REACTION PROCESS JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2011-03-03 US disclosed
EP-2258477-A1 CATALYST AND REACTION PROCESS Japan Science and Technology Agency (JP) 2010-12-08 EP disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed
WO-2009096409-A1 CATALYST AND REACTION PROCESS JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2009-08-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260061069-A1 SIZE-TUNABLE SYNTHETIC PARTICLES FOR IMMUNE CELL ACTIVATION ICOS, CD47, CD4 PDPK1 2983/4885POLB 1843/4885KMT2A 2651/4885
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB PDPK1 109/4885POLB 4008/4885KMT2A 1777/4885
US-20110054190-A1 CATALYST AND REACTION PROCESS ME1, MAL2, ME2 PDPK1 4324/4885POLB 859/4885KMT2A 2297/4885
US-20250389633-A1 SYNTHETIC HUMAN CELL MIMIC PARTICLE FOR CYTOMETRIC OR COULTER DEVICE CD4, ICOS, CD69 PDPK1 3880/4885POLB 3086/4885KMT2A 2367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.