SCHEMBL6582673

SCHEMBL6582673

COc1cc(CCC2OCCO2)ccc1OCc1nc(-c2ccccc2)oc1C

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.49
KDR P35968 1/20 0.48
PPARG P37231 7/20 0.48
MAPT P10636 2/20 0.45
PPARA Q07869 5/20 0.45
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
USP2 O75604 2/20 0.43
LMNA P02545 2/20 0.43
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6580905 0.94 PPARG (0.53) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6584539 0.93 PPARG (0.49) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6584386 0.93 PPARG (0.49) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6583469 0.88 KDR (0.44) FFAR1KDRPPARGMAPTPPARA
SCHEMBL4038141 0.84 KDR (0.67) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6583779 0.83 KDR (0.53) FFAR1KDRPPARGMAPTPPARA
SCHEMBL1731684 0.82 KDR (0.53) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6583506 0.82 FFAR1 (0.52) FFAR1KDRPPARGMAPTPPARA
SCHEMBL4843985 0.81 FFAR1 (0.59) FFAR1KDRPPARGMAPTPPARA
SCHEMBL6584236 0.81 PPARG (0.71) FFAR1KDRPPARGMAPTPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0710659-B1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2004-01-28 EP disclosed
EP-0710659-A1 Oxazolidinedione derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-08 EP disclosed