Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258762 | 0.83 | CYP3A4 (0.46) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL19113609 | 0.80 | CYP3A4 (0.41) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL16955750 | 0.78 | TP53 (0.44) | CYP3A4ERN1TDP1ALDH1A1POLB | |
| SCHEMBL22171539 | 0.78 | CYP3A4 (0.50) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL28030980 | 0.76 | CYP3A4 (0.48) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL29957786 | 0.74 | ERN1 (0.57) | CYP3A4ERN1TDP1ALDH1A1POLB | |
| SCHEMBL7820969 | 0.74 | CYP3A4 (0.46) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL9729264 | 0.74 | TDP1 (0.56) | CYP3A4TDP1ALDH1A1GAAMAPT | |
| SCHEMBL16960087 | 0.74 | CYP3A4 (0.46) | CYP3A4IDO1ERN1RAPGEF4TDP1 | |
| SCHEMBL692253 | 0.74 | ERN1 (0.57) | CYP3A4ERN1TDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390354-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | Amgen Inc. (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |